Panama Canal Luxury Cruises

Browse all available sailing dates for luxury cruise holidays to the Panama Canal. To find out more and to discover the best deals call us today and speak to our cruise experts. All Pnama Canal cruise holidays are fully ABTA & ATOL protected.

Find Out More About Panama Canal Cruising

Showing 30 out of 230 cruises
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Fly Cruise From:
Was £9354pp Now: £8040pp

Exotic Coasts & Casco Viejo

Miami | Costa Maya | Harvest Caye | Roatán Island | Georgetown | Ocho Rios | Puerto Limón | Cartagena | Colón | Panama City | Colón | Panama City

  • 23 Feb 2027
  • 14 Nights
EXCLUSIVE $400 onboard spend* - ONLY when booking with SixStarCruises
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £9354pp Now: £8040pp
View cruise Enquire Enquire
REF: REGENTGRA270223
Fly Cruise From:
Was £52795pp Now: £50683pp

Ultimate Journey: Antarctica & South America

Buenos Aires | Ushuaia | Antarctic Peninsula | Ushuaia | Cape Horn | Chilean Fjords | Punta Arenas | Puerto Edén | PIO X Glacier | Castro | Puerto Montt | Niebla | Valparaiso | Pingüino de Humboldt National Reserve | Paracas | Salaverry | Manta | Utría National Park | Ensenada de Utria | Darién National Park | Playa del Muerto | Panama City | San Blas Islands | Cartagena | Cabo de la Vela | Willemstad | Tobago Cays | Mayreau Island | Soufrière | Bridgetown

  • 25 Feb 2027
  • 48 Nights
Fly Cruise From:
Was £52795pp Now: £50683pp
View cruise Enquire Enquire
REF: SCENIC104S250227-1
Fly Cruise From:
Was £4775pp Now: £3369pp

Roundtrip Fort Lauderdale

Fort Lauderdale | Colón | Puerto Limón | Roatán Island | Belize City | Cozumel | Fort Lauderdale

  • 26 Feb 2027
  • 10 Nights
Up to 30% OFF per suite
Receive up to £3,000 Caribbean Air Credit
Fly Cruise From:
Was £4775pp Now: £3369pp
View cruise Enquire Enquire
REF: CRYSTALCSY-010-270226
Cruise From:
£4790pp

Central America Jewels & Panama Canal

Colón | San Blas Islands | Fuerte Amador | Darién National Park | Golfito | Puntarenas

  • 26 Feb 2027
  • 7 Nights
Cruise From:
£4790pp
View cruise Enquire Enquire
REF: PONANTER260227
Cruise From:
Was £5499pp Now: £5334pp

San Antonio to Fort Lauderdale

San Antonio | Coquimbo | Arica | Callao | Manta | Fuerte Amador | Aruba | Fort Lauderdale

  • 28 Feb 2027
  • 19 Nights
NEW! Low deposit from ONLY £100pp*
Cruise From:
Was £5499pp Now: £5334pp
View cruise Enquire Enquire
REF: CUNARDH706
Fly Cruise From:
Was £9109pp Now: £8835pp

San Antonio to Southampton

San Antonio | Coquimbo | Arica | Callao | Manta | Fuerte Amador | Aruba | Fort Lauderdale | Port Canaveral | Ponta Delgada | Southampton

  • 28 Feb 2027
  • 33 Nights
Fly Cruise From:
Was £9109pp Now: £8835pp
View cruise Enquire Enquire
REF: CUNARDH706A
Fly Cruise From:
Was £10199pp Now: £9893pp

San Antonio to Hamburg

San Antonio | Coquimbo | Arica | Callao | Manta | Fuerte Amador | Aruba | Fort Lauderdale | Port Canaveral | Ponta Delgada | Southampton | Zeebrugge | Hamburg

  • 28 Feb 2027
  • 36 Nights
Fly Cruise From:
Was £10199pp Now: £9893pp
View cruise Enquire Enquire
REF: CUNARDH706B

Finest Collection

Holiday prices from:
£9599pp

Machu Picchu Discovery & 6* Mayan Ruin Cruise

Callao | Salaverry | Guayaquil | Manta | Golfito | Panama City | Puerto Limón | Roatán Island | Harvest Caye | Costa Maya | Miami

  • 05 Mar 2027
  • 22 Nights
Tours in Cuzco to allow for indepth destination immersion
5* hotel stays in Lima and Cuzco
16-night ultra-luxury all-inclusive cruise
Return flights included!
Holiday prices from:
£9599pp
View cruise
REF: REGENTMAR270310-2
Tours in Cuzco to allow for indepth destination immersion
5* hotel stays in Lima and Cuzco
16-night ultra-luxury all-inclusive cruise
Return flights included!
Fly Cruise From:
Was £3999pp Now: £3159pp

Panama Potpourri

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City

  • 05 Mar 2027
  • 10 Nights
Save up to 50%* - book before prices increase!
Choose between FREE Wine, Beer & Champagne by the glass with lunch and dinner OR shore excursion credit
Fly Cruise From:
Was £3999pp Now: £3159pp
View cruise Enquire Enquire
REF: OCEANIAMNA270305
Fly Cruise From:
Was £5979pp Now: £5650pp

Panama Canal Navigator

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City | Cartagena | Santa Marta | Oranjestad | Willemstad | Falmouth | Georgetown | Miami

  • 05 Mar 2027
  • 20 Nights
Choose between FREE Wine, Beer & Champagne by the glass with lunch and dinner OR shore excursion credit
Fly Cruise From:
Was £5979pp Now: £5650pp
View cruise Enquire Enquire
REF: OCEANIAMNA270305A
Cruise From:
£4040pp

Central America Jewels & Panama Canal

Puntarenas | Golfito | Darién National Park | Fuerte Amador | San Blas Islands | Colón

  • 05 Mar 2027
  • 7 Nights
Cruise From:
£4040pp
View cruise Enquire Enquire
REF: PONANTER050327
Cruise From:
Was £13800pp Now: £13110pp

Valparaiso to Miami

Valparaiso | Arica | Callao | Guayaquil | Panama City | Cozumel | Miami

  • 05 Mar 2027
  • 18 Nights
Enjoy $960 shore excursion credit when booking ALL-INCLUSIVE PLUS
Cruise From:
Was £13800pp Now: £13110pp
View cruise Enquire Enquire
REF: SILVERSN270305018
Fly Cruise From:
Was £16189pp Now: £15379pp

11 Nt Panama Canal & Southern Caribbean

Fort Lauderdale | Cartagena | Colón | Cartagena | Oranjestad | Willemstad | Kralendijk | Fort Lauderdale

  • 08 Mar 2027
  • 11 Nights
Fly Cruise From:
Was £16189pp Now: £15379pp
View cruise Enquire Enquire
REF: CELEBAT11C025-080327
Fly Cruise From:
Was £17834pp Now: £16942pp

Journey To The Amazon

Panama City | Oranjestad | Port-of-Spain | Manaus | Boca de Valeria | Alter do Chão | Saint George's | Willemstad | Panama City

  • 09 Mar 2027
  • 22 Nights
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £17834pp Now: £16942pp
View cruise Enquire Enquire
REF: REGENTGRA270309
Fly Cruise From:
Was £8370pp Now: £7951pp

Machu Picchu & Mayan Ruins

Callao | Salaverry | Guayaquil | Manta | Golfito | Panama City | Puerto Limón | Roatán Island | Harvest Caye | Costa Maya | Miami

  • 10 Mar 2027
  • 16 Nights
Exquisite Escapes Sale - Save up to 50%*
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £8370pp Now: £7951pp
View cruise Enquire Enquire
REF: REGENTMAR270310
Cruise From:
Was £3709pp Now: £3560pp

Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel

San Antonio | Coquimbo | Iquique | Arica | Pisco | Callao | Fuerte Amador | Puerto Limón | San Andrés Island | Cozumel | Miami

  • 10 Mar 2027
  • 19 Nights
Up to $750 onboard spend
Cruise From:
Was £3709pp Now: £3560pp
View cruise Enquire Enquire
REF: AZJR270310-019
Cruise From:
£5390pp

Panama, Colombia & Caribbean Islands

Colón | San Blas Islands | Cartagena | Santa Marta | Bonaire | Tobago Cays | Pigeon Island | Soufrière | Îles des Saintes | Fort-de-France

  • 12 Mar 2027
  • 10 Nights
Cruise From:
£5390pp
View cruise Enquire Enquire
REF: PONANTER120327
Fly Cruise From:
Was £3531pp Now: £3336pp

Panama & Pristine Isles

Panama City | Cartagena | Santa Marta | Oranjestad | Willemstad | Falmouth | Georgetown | Miami

  • 15 Mar 2027
  • 10 Nights
Save up to 50%* - book before prices increase!
Choose between FREE Wine, Beer & Champagne by the glass with lunch and dinner OR shore excursion credit
Fly Cruise From:
Was £3531pp Now: £3336pp
View cruise Enquire Enquire
REF: OCEANIAMNA270315
Fly Cruise From:
Was £18123pp Now: £17398pp

Ultimate South America to the Caribbean through the Panama Canal

Valparaiso | Pingüino de Humboldt National Reserve | Paracas | Salaverry | Manta | Utría National Park | Ensenada de Utria | Darién National Park | Playa del Muerto | Panama City | San Blas Islands | Cartagena | Cabo de la Vela | Willemstad | Tobago Cays | Mayreau Island | Soufrière | Bridgetown

  • 21 Mar 2027
  • 24 Nights
Fly Cruise From:
Was £18123pp Now: £17398pp
View cruise Enquire Enquire
REF: SCENIC132C210327-2
Fly Cruise From:
Was £8986pp Now: £8626pp

Ancient Kingdoms and Natural Treasures: Chile to Panama

Valparaiso | Pingüino de Humboldt National Reserve | Paracas | Salaverry | Manta | Utría National Park | Ensenada de Utria | Darién National Park | Playa del Muerto | Panama City

  • 21 Mar 2027
  • 13 Nights
Fly Cruise From:
Was £8986pp Now: £8626pp
View cruise Enquire Enquire
REF: SCENIC801L210327-2
Cruise From:
£13000pp

Secrets of Central America

Puntarenas | Curú Wildlife Refuge | Bahía Drake | Coiba Island | Darién National Park | Pearl Islands | San Blas Islands | Fuerte San Lorenzo | Colón

  • 29 Mar 2027
  • 10 Nights
Cruise From:
£13000pp
View cruise Enquire Enquire
REF: PONANTEE290327
Fly Cruise From:
Was £7969pp Now: £7570pp

Carnival Of Caribbean Colors

Panama City | Cartagena | Santa Marta | Oranjestad | Willemstad | Kralendijk | Saint George's | Castries | Gustavia | Tortola | Miami

  • 31 Mar 2027
  • 14 Nights
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £7969pp Now: £7570pp
View cruise Enquire Enquire
REF: REGENTGRA270331
Fly Cruise From:
Was £10190pp Now: £9782pp

Panama Canal & the Americas

Valparaiso | Iquique | Callao | Fuerte Amador | Port Antonio | Inagua | San Salvador Island | New York

  • 01 Apr 2027
  • 19 Nights
Receive a FREE Silver Spirits Drinks Package on ALL Ocean and Expedition voyages
Fly Cruise From:
Was £10190pp Now: £9782pp
View cruise Enquire Enquire
REF: VIKINGXOC270401
Fly Cruise From:
Was £9515pp Now: £8758pp

Pristine islands of the Caribbean & the Panama Canal

Panama City | San Blas Islands | Cartagena | Cabo de la Vela | Willemstad | Tobago Cays | Mayreau Island | Soufrière | Bridgetown

  • 03 Apr 2027
  • 11 Nights
Fly Cruise From:
Was £9515pp Now: £8758pp
View cruise Enquire Enquire
REF: SCENIC131C030427-2
Cruise From:
Was £9750pp Now: £9262pp

A Grand Journey through Balmy Shores & Enchanting Nature to Panama’s Wonders

San Juan (Puerto Rico) | Gustavia | Little Bay | Basseterre | Key West | Miami | Ocho Rios | Willemstad | Oranjestad | Santa Marta | Cartagena | Panama City | Cartagena | Panama City

  • 05 Apr 2027
  • 17 Nights
Save up to 25% PLUS up to £2,600 Explora Credit
Cruise From:
Was £9750pp Now: £9262pp
View cruise Enquire Enquire
REF: EXPLORAEL20270405SJUAMD
Cruise From:
£5660pp

Panama, Colombia & Caribbean Islands

Colón | San Blas Islands | Cartagena | Santa Marta | Bonaire | Mayreau Island | Pigeon Island | Soufrière | Îles des Saintes | Fort-de-France

  • 08 Apr 2027
  • 10 Nights
Cruise From:
£5660pp
View cruise Enquire Enquire
REF: PONANTEE080427
Cruise From:
Was £6885pp Now: £6540pp

A Journey through Enchanting Nature & the Marvels of the Panama Canal

Miami | Ocho Rios | Willemstad | Oranjestad | Santa Marta | Cartagena | Panama City | Cartagena | Panama City

  • 12 Apr 2027
  • 10 Nights
Save up to 25% PLUS up to £2,600 Explora Credit
Cruise From:
Was £6885pp Now: £6540pp
View cruise Enquire Enquire
REF: EXPLORAEL20270412MIAAMD
Cruise From:
Was £12440pp Now: £11818pp

An Extended Journey from Majestic Horizons to Mayan Gems

Miami | Ocho Rios | Willemstad | Oranjestad | Santa Marta | Cartagena | Panama City | Cartagena | Panama City | Acajutla | Puerto Quetzal | Puerto Madero | Huatulco (Santa María Huatulco) | Puerto Vallarta | Los Angeles

  • 12 Apr 2027
  • 21 Nights
Save up to 25% PLUS up to £2,600 Explora Credit
Cruise From:
Was £12440pp Now: £11818pp
View cruise Enquire Enquire
REF: EXPLORAEL20270412MIALAX

Cruise & Stay

Holiday prices from:
£6299pp

5* Panama City Stay with A Journey of Mayan Discovery & Mexican Exploration

Panama City | Acajutla | Puerto Quetzal | Puerto Madero | Huatulco (Santa María Huatulco) | Puerto Vallarta | Los Angeles

  • 20 Apr 2027
  • 14 Nights
FREE 5* hotel stay in Panama City
FREE private tour of Panama City & Panama Canal
EXCLUSIVE offer to SixStarCruises
Holiday prices from:
£6299pp
View cruise
REF: EXPLORAEL20270422AMDLAX-2
FREE 5* hotel stay in Panama City
FREE private tour of Panama City & Panama Canal
EXCLUSIVE offer to SixStarCruises
Cruise From:
Was £5480pp Now: £5206pp

A Journey of Mayan Discovery & Mexican Exploration

Panama City | Acajutla | Puerto Quetzal | Puerto Madero | Huatulco (Santa María Huatulco) | Puerto Vallarta | Los Angeles

  • 22 Apr 2027
  • 11 Nights
Save up to 25% PLUS up to £2,600 Explora Credit
Cruise From:
Was £5480pp Now: £5206pp
View cruise Enquire Enquire
REF: EXPLORAEL20270422AMDLAX

Prices are subject to change and availability. Prices may vary depending on the airport selected. Promotions are only applicable to select cabin grades, please call for details.

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