Luxury Central America Cruises

Situated between North and South America, Central America is a small but captivating stretch of land home to a number of distinctive, culturally-rich and naturally beautiful nations to uncover on a luxury cruise getaway with some of the world's finest SixStarCruises™

Find Out More About Cruising to Central America

Showing 30 out of 454 cruises
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Fly Cruise From:
Was £2512pp Now: £2386pp

7 Night Grand Cayman, Mexico & Bahamas

Fort Lauderdale | Bimini Island | Georgetown | Cozumel | Costa Maya | Fort Lauderdale

  • 07 Feb 2027
  • 7 Nights
Fly Cruise From:
Was £2512pp Now: £2386pp
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REF: CELEBBY07W721-070227
Fly Cruise From:
Was £5284pp Now: £5019pp

Mystical Maya

Miami | Cozumel | Roatán Island | Harvest Caye | Costa Maya | Miami

  • 09 Feb 2027
  • 7 Nights
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £5284pp Now: £5019pp
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REF: REGENTGRA270209
Fly Cruise From:
Was £7074pp Now: £6720pp

Sapphire Sojourn

Los Angeles | Cabo San Lucas | Mazatlán | Acapulco | Puerto Quetzal | Puntarenas | Panama City

  • 10 Feb 2027
  • 12 Nights
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £7074pp Now: £6720pp
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REF: REGENTPRT270210
Cruise From:
£11211pp

Baja and the Sea of Cortez: In Search of the Great Whales – with Smithsonian Journeys

Cabo San Lucas | Guerrero Negro | Magdalenefjord | Cabo Pulmo National Park | Loreto | Coronado | Isla Los Islotes | La Paz | Cabo San Lucas

  • 10 Feb 2027
  • 10 Nights
Cruise From:
£11211pp
View cruise Enquire Enquire
REF: PONANTEE100227
Fly Cruise From:
Was £4884pp Now: £4639pp

7 Night Bahamas, Mexico & Cayman

Miami | Nassau | Georgetown | Cozumel | Costa Maya | Miami

  • 14 Feb 2027
  • 7 Nights
Fly Cruise From:
Was £4884pp Now: £4639pp
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REF: CELEBXC07E474-140227
Fly Cruise From:
Was £4415pp Now: £4194pp

Rum, Roatan & Ruins

Miami | Cozumel | Belize City | Roatán Island | Costa Maya | Miami

  • 16 Feb 2027
  • 7 Nights
Exquisite Escapes Sale - Save up to 50%*
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £4415pp Now: £4194pp
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REF: REGENTGRA270216
Cruise From:
Was £12629pp Now: £12123pp

Buenos Aires to Miami Grand Voyage

Buenos Aires | Montevideo | Punta del Este | Port Stanley | Ushuaia | Punta Arenas | Chilean Fjords | Puerto Chacabuco | Puerto Montt | San Antonio | Coquimbo | Iquique | Arica | Pisco | Callao | Fuerte Amador | Puerto Limón | San Andrés Island | Cozumel | Miami

  • 17 Feb 2027
  • 40 Nights
Included in your Grand Voyage: Complimentary Airfare | Shore Excursion Credit | Upgrade Beverage package | WiFi for Two Devices | Weekly Laundry Service
Cruise From:
Was £12629pp Now: £12123pp
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REF: AZJR270217-040
Cruise From:
£6040pp

Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys

Puntarenas | Quepos (Puerto Quepos) | Darién National Park | Fuerte Amador | San Blas Islands | Colón

  • 19 Feb 2027
  • 7 Nights
Cruise From:
£6040pp
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REF: PONANTER190227
Fly Cruise From:
Was £3118pp Now: £2962pp

7 Night Key West, Mexico & Cayman

Port Canaveral | Key West | Bimini Island | Georgetown | Cozumel | Port Canaveral

  • 20 Feb 2027
  • 7 Nights
Fly Cruise From:
Was £3118pp Now: £2962pp
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REF: CELEBAX07W681-200227
Fly Cruise From:
Was £9354pp Now: £8040pp

Exotic Coasts & Casco Viejo

Miami | Costa Maya | Harvest Caye | Roatán Island | Georgetown | Ocho Rios | Puerto Limón | Cartagena | Colón | Panama City | Colón | Panama City

  • 23 Feb 2027
  • 14 Nights
EXCLUSIVE $400 onboard spend* - ONLY when booking with SixStarCruises
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £9354pp Now: £8040pp
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REF: REGENTGRA270223
Fly Cruise From:
Was £52795pp Now: £50683pp

Ultimate Journey: Antarctica & South America

Buenos Aires | Ushuaia | Antarctic Peninsula | Ushuaia | Cape Horn | Chilean Fjords | Punta Arenas | Puerto Edén | PIO X Glacier | Castro | Puerto Montt | Niebla | Valparaiso | Pingüino de Humboldt National Reserve | Paracas | Salaverry | Manta | Utría National Park | Ensenada de Utria | Darién National Park | Playa del Muerto | Panama City | San Blas Islands | Cartagena | Cabo de la Vela | Willemstad | Tobago Cays | Mayreau Island | Soufrière | Bridgetown

  • 25 Feb 2027
  • 48 Nights
Fly Cruise From:
Was £52795pp Now: £50683pp
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REF: SCENIC104S250227-1
Fly Cruise From:
Was £4775pp Now: £3369pp

Roundtrip Fort Lauderdale

Fort Lauderdale | Colón | Puerto Limón | Roatán Island | Belize City | Cozumel | Fort Lauderdale

  • 26 Feb 2027
  • 10 Nights
Up to 30% OFF per suite
Receive up to £3,000 Caribbean Air Credit
Fly Cruise From:
Was £4775pp Now: £3369pp
View cruise Enquire Enquire
REF: CRYSTALCSY-010-270226
Cruise From:
£4790pp

Central America Jewels & Panama Canal

Colón | San Blas Islands | Fuerte Amador | Darién National Park | Golfito | Puntarenas

  • 26 Feb 2027
  • 7 Nights
Cruise From:
£4790pp
View cruise Enquire Enquire
REF: PONANTER260227
Cruise From:
Was £5499pp Now: £5334pp

San Antonio to Fort Lauderdale

San Antonio | Coquimbo | Arica | Callao | Manta | Fuerte Amador | Aruba | Fort Lauderdale

  • 28 Feb 2027
  • 19 Nights
NEW! Low deposit from ONLY £100pp*
Cruise From:
Was £5499pp Now: £5334pp
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REF: CUNARDH706
Fly Cruise From:
Was £9109pp Now: £8835pp

San Antonio to Southampton

San Antonio | Coquimbo | Arica | Callao | Manta | Fuerte Amador | Aruba | Fort Lauderdale | Port Canaveral | Ponta Delgada | Southampton

  • 28 Feb 2027
  • 33 Nights
Fly Cruise From:
Was £9109pp Now: £8835pp
View cruise Enquire Enquire
REF: CUNARDH706A
Fly Cruise From:
Was £10199pp Now: £9893pp

San Antonio to Hamburg

San Antonio | Coquimbo | Arica | Callao | Manta | Fuerte Amador | Aruba | Fort Lauderdale | Port Canaveral | Ponta Delgada | Southampton | Zeebrugge | Hamburg

  • 28 Feb 2027
  • 36 Nights
Fly Cruise From:
Was £10199pp Now: £9893pp
View cruise Enquire Enquire
REF: CUNARDH706B
Fly Cruise From:
Was £2365pp Now: £2246pp

7 Night Grand Cayman, Mexico & Bahamas

Fort Lauderdale | Nassau | Cozumel | Georgetown | Fort Lauderdale

  • 28 Feb 2027
  • 7 Nights

Interest free Monthly Payments from JUST £244pp

Fly Cruise From:
Was £2365pp Now: £2246pp
View cruise Enquire Enquire
REF: CELEBBY07W678-280227
Cruise From:
£9588pp

Exploration in the Heart of Baja California

Cabo San Lucas | Guerrero Negro | Magdalenefjord | Cabo Pulmo National Park | Loreto | Coronado | La Paz | Isla Los Islotes | Cabo San Lucas

  • 02 Mar 2027
  • 10 Nights
Cruise From:
£9588pp
View cruise Enquire Enquire
REF: PONANTEE020327

Finest Collection

Holiday prices from:
£9599pp

Machu Picchu Discovery & 6* Mayan Ruin Cruise

Callao | Salaverry | Guayaquil | Manta | Golfito | Panama City | Puerto Limón | Roatán Island | Harvest Caye | Costa Maya | Miami

  • 05 Mar 2027
  • 22 Nights
Tours in Cuzco to allow for indepth destination immersion
5* hotel stays in Lima and Cuzco
16-night ultra-luxury all-inclusive cruise
Return flights included!
Holiday prices from:
£9599pp
View cruise
REF: REGENTMAR270310-2
Tours in Cuzco to allow for indepth destination immersion
5* hotel stays in Lima and Cuzco
16-night ultra-luxury all-inclusive cruise
Return flights included!
Fly Cruise From:
Was £3999pp Now: £3159pp

Panama Potpourri

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City

  • 05 Mar 2027
  • 10 Nights
Save up to 50%* - book before prices increase!
Choose between FREE Wine, Beer & Champagne by the glass with lunch and dinner OR shore excursion credit
Fly Cruise From:
Was £3999pp Now: £3159pp
View cruise Enquire Enquire
REF: OCEANIAMNA270305
Fly Cruise From:
Was £5979pp Now: £5650pp

Panama Canal Navigator

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City | Cartagena | Santa Marta | Oranjestad | Willemstad | Falmouth | Georgetown | Miami

  • 05 Mar 2027
  • 20 Nights
Choose between FREE Wine, Beer & Champagne by the glass with lunch and dinner OR shore excursion credit
Fly Cruise From:
Was £5979pp Now: £5650pp
View cruise Enquire Enquire
REF: OCEANIAMNA270305A
Cruise From:
£4040pp

Central America Jewels & Panama Canal

Puntarenas | Golfito | Darién National Park | Fuerte Amador | San Blas Islands | Colón

  • 05 Mar 2027
  • 7 Nights
Cruise From:
£4040pp
View cruise Enquire Enquire
REF: PONANTER050327
Cruise From:
Was £13800pp Now: £13110pp

Valparaiso to Miami

Valparaiso | Arica | Callao | Guayaquil | Panama City | Cozumel | Miami

  • 05 Mar 2027
  • 18 Nights
Enjoy $960 shore excursion credit when booking ALL-INCLUSIVE PLUS
Cruise From:
Was £13800pp Now: £13110pp
View cruise Enquire Enquire
REF: SILVERSN270305018
Fly Cruise From:
Was £2501pp Now: £2375pp

7 Night Key West, Mexico & Cayman

Port Canaveral | Key West | Georgetown | Cozumel | Port Canaveral

  • 06 Mar 2027
  • 7 Nights
Fly Cruise From:
Was £2501pp Now: £2375pp
View cruise Enquire Enquire
REF: CELEBAX07W681-060327
Fly Cruise From:
Was £3855pp Now: £3662pp

7 Night Bahamas, Mexico & Cayman

Miami | Nassau | Georgetown | Cozumel | Costa Maya | Miami

  • 07 Mar 2027
  • 7 Nights
Fly Cruise From:
Was £3855pp Now: £3662pp
View cruise Enquire Enquire
REF: CELEBXC07E474-070327
Fly Cruise From:
Was £16189pp Now: £15379pp

11 Nt Panama Canal & Southern Caribbean

Fort Lauderdale | Cartagena | Colón | Cartagena | Oranjestad | Willemstad | Kralendijk | Fort Lauderdale

  • 08 Mar 2027
  • 11 Nights
Fly Cruise From:
Was £16189pp Now: £15379pp
View cruise Enquire Enquire
REF: CELEBAT11C025-080327
Cruise From:
Was £40778pp Now: £36292pp

83-Day World Cruise: Australia In-Depth & Panama Canal

Sydney | Hobart | Burnie | Melbourne | Adelaide | Kangaroo Island | Wallaroo | Port Lincoln | Albany | Busselton | Perth | Geraldton | Exmouth | Broome | Kimberley Coast | Darwin | Alotau | Cairns | Townsville | Airlie Beach | Brisbane | Norfolk Island | Nouméa | Mystery Island (Inyeug) | Lautoka | Suva | Savusavu | Apia | Honolulu | Kailua-Kona | Long Beach | Puerto Vallarta | Huatulco (Santa María Huatulco) | Puerto Chiapas | Puerto Quetzal | Puntarenas | Cartagena | Miami

  • 09 Mar 2027
  • 83 Nights
Receive up to $1,000 onboard spend per couple
Cruise From:
Was £40778pp Now: £36292pp
View cruise Enquire Enquire
REF: SBN6722A
Fly Cruise From:
Was £17834pp Now: £16942pp

Journey To The Amazon

Panama City | Oranjestad | Port-of-Spain | Manaus | Boca de Valeria | Alter do Chão | Saint George's | Willemstad | Panama City

  • 09 Mar 2027
  • 22 Nights
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £17834pp Now: £16942pp
View cruise Enquire Enquire
REF: REGENTGRA270309
Fly Cruise From:
Was £8370pp Now: £7951pp

Machu Picchu & Mayan Ruins

Callao | Salaverry | Guayaquil | Manta | Golfito | Panama City | Puerto Limón | Roatán Island | Harvest Caye | Costa Maya | Miami

  • 10 Mar 2027
  • 16 Nights
Exquisite Escapes Sale - Save up to 50%*
Book now with a 7.5% low deposit*
Fly Cruise From:
Was £8370pp Now: £7951pp
View cruise Enquire Enquire
REF: REGENTMAR270310
Cruise From:
Was £3709pp Now: £3560pp

Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel

San Antonio | Coquimbo | Iquique | Arica | Pisco | Callao | Fuerte Amador | Puerto Limón | San Andrés Island | Cozumel | Miami

  • 10 Mar 2027
  • 19 Nights
Up to $750 onboard spend
Cruise From:
Was £3709pp Now: £3560pp
View cruise Enquire Enquire
REF: AZJR270310-019

Prices are subject to change and availability. Prices may vary depending on the airport selected. Promotions are only applicable to select cabin grades, please call for details.

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